A resin is a solid chromatographic support material composed of a porous matrix — typically agarose, silica, or polymeric beads — functionalized with specific ligands that enable the selective capture, separation, and purification of target biomolecules based on affinity, charge, size, or hydrophobicity. Resins are a critical component of downstream processing in biopharmaceutical manufacturing, with widely used examples including Protein A resins for monoclonal antibody purification, ion exchange resins for charge-based separation, and affinity resins for viral vector purification. Resin selection, lifetime studies, sanitization, and validation are key considerations in process development and regulatory submissions.
