Mammalian systems refer to cell culture platforms based on mammalian cell lines — such as CHO (Chinese Hamster Ovary), HEK293, NS0, and PER.C6 — used for the production of complex biopharmaceutical products requiring human-like post-translational modifications (PTMs), including glycosylation, folding, and disulfide bond formation. They represent the gold standard for the manufacturing of monoclonal antibodies (mAbs), recombinant proteins, viral vectors, and advanced therapy products, and account for the largest share of the biopharmaceutical CDMO market due to their ability to produce biologically active, clinically relevant molecules at commercial scale.
