A lentiviral vector (LVV) is a genetically engineered, replication-incompetent delivery system derived from lentivirus — typically HIV-1 — designed to stably introduce therapeutic genetic material into target cells through chromosomal integration. Unlike AAV or adenoviral vectors, lentiviral vectors are capable of permanently modifying both dividing and non-dividing cells, making them the preferred vector platform for ex vivo gene therapy applications such as CAR-T cell manufacturing, hematopoietic stem cell (HSC) gene therapy, and TCR-T cell therapy.
